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Open access Sep 2026

Broadly reactive antibodies against influenza B virus hemagglutinin neutralize and protect through distinct structural mechanisms

ABSTRACT Influenza B viruses contribute substantially to seasonal disease burden; however, the structural basis by which antibodies recognize the major glycoprotein hemagglutinin (HA) and mediate antiviral activity remains incompletely defined. Influenza B virus used to circulate as two antigenically distinct lineages,...

D. Bhavsar, Alesandro Civljak, Bruno Bonnettaz et al. · 0 citations
Review Open access Sep 2026

What Antibody Repertoires See: Structural and Immunogenetic Insights Into Influenza A Virus Hemagglutinin Recognition

Human infection with or vaccination against influenza A virus has been one of the most informative systems for understanding how human antibody repertoires recognize viral glycoproteins. Decades of antibody isolation, repertoire sequencing, lineage tracing, serology, viral antigenic evolution, and structural biology ha...

Bruno Bonnettaz, G. Bajic · 0 citations

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