Myocardial infarction (MI) is characterized by extensive immune activation and dynamic remodeling of the cardiac microenvironment, in which myeloid cells play critical roles in regulating inflammation and tissue repair. However, the cellular heterogeneity, developmental trajectories, and intercellular communication...
Zhen-Zhen Zhao, Xu-Heng Dou, Fu Zhao et al.· BIO Integration· 0 citations
Background Pain following traumatic brain injury (TBI) is a major challenge in clinical management. Neuroinflammatory responses, particularly those involving microglia, are increasingly implicated in the synaptic and circuit‐level remodeling associated with post‐TBI pain. However, the conventional M1/M2 framework does...
Fu Zhao, Jing-Ru Shi, Yi-Min Zhang et al.· Pain Research and Management· 0 citations
This study identifies a TBI-associated C3 Osmr+ astrocyte subpopulation characterized by the highest pan-reactive signature together with protection-associated, neurotoxicity-associated, and metabolic gene expression features, and identifies C0 Cox6b1+ glutamatergic neurons as a candidate recipient population of astroc...
Fu Zhao, Lu-Xi Cao, Jia-Nan Chen et al.· Brain Research· 0 citations
Findings delineate dynamic NK subpopulation remodeling during SIRS and validate IGF1/IGF1R as a potential key pathway governing NK effector function, providing a transcriptomic basis for identifying candidate biomarkers and potential therapeutic targets in SIRS.
Hong-Ling Jia, Hang Zhao, Yan Li et al.· Clinical and Experimental Me...· 0 citations
This review highlights mechanistic roles of exosomes in melanoma progression, summarizes key liquid-biopsy biomarkers, and discusses translational barriers such as standardization, scalable manufacturing, safety, and clinical validation.
Li Li, Xin Zheng, Jingrui Shi et al.· Microstructures· 0 citations
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