Author

Fu-Jian Wan

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Open access Sep 2026

A highly potent bispecific antibody confers complete protection against SFTSV in preclinical models.

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging bunyavirus that causes severe human disease, with a case fatality rate of up to 30%. However, no licensed therapeutics are currently available for clinical use. Here, we identified two SFTSV neutralizing nanobodies (Nbs), N2C1 and N2D2, which inhi...

Xiao-Ping Guo, Fu-Jian Wan, Wu-Jian Li et al. · Proceedings of the National... · 0 citations

Open access Oct 2026

Fusion-loop-engineered Zika mRNA vaccine elicits convergent B cell immunodominance to uncouple protection from ADE in macaques.

Antibody-dependent enhancement (ADE) remains a major hurdle for flavivirus vaccine development. Engineering the fusion loop (FL) represents a promising solution, yet validations restricted to murine models limit human translatability due to profound species divergence. Here, we provide a primate-level demonstration tha...

Chen-Xi Yang, Shu-Xin Guo, Ya-Ming Lu et al. · Cell Reports Medicine · 0 citations