While singlet oxygen (1O2)-based therapies like photodynamic therapy (PDT) demonstrate clinical anticancer efficacy, their dependence on external light and substantial O2 consumption significantly limits their broader application. To surmount these constraints, we develop a chemiexcited (light-independent) PDT platform...
Ru-Feng Zhang, Xiao-Yang Liu, Shi-Hao Wang et al.· Small· 0 citations
Cancer-associated fibroblasts (CAFs) act as key drivers of cancer progression and therapeutic resistance within the tumor microenvironment, but their diverse and context-dependent functions complicate therapeutic targeting. The limited clinical efficacy of CAF-targeting therapeutics has prompted a critical reassessment...
Yan-Ping Jiang, Bo Ding, Han Yin et al.· Journal of Hematology & Onco...· 0 citations
This work constructs an injectable hydrogel (IVH@gel) via the coordination between calcium ions and sodium alginate to encapsulate the PTA Hu Kaiwen Ink, the free radical initiator 2,2’‐azobis[2‐(2‐imidazolin‐2‐yl)propane]dihydrochloride, and the autophagy inhibitor hydroxychloroquine for realizing synergistic PTT and...