Author

Frederik J. Verweij

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Open access Aug 2026

TSPAN3 defines a distinct intracellular trafficking route to secretory multivesicular bodies

The findings identify TSPAN3 as a marker of a previously unrecognized secretory MVB population distinguished by its intracellular trafficking, molecular interactions, and EV composition, supporting a model in which distinct tetraspanin-organized membrane nanodomains are associated with different intracellular trafficki...

Jelle van den Bor, Misko Bobeldijk, C. A. Zala et al. · bioRxiv · 0 citations

Open access Jul 2026

CRISPR activation screen uncovers MARCKSL1 as a gauge for extracellular vesicle secretion.

How cells balance these competing routes using a genome-wide CRISPR activation screen for factors that alter surface expression of CD63-an EV-associated tetraspanin that shuttles between the PM and endosomes is investigated.

Yingjie Zhong, Anna E. George, Roman I. Koning et al. · Cell Reports · 0 citations