Asymmetric Boost Responses to an HIV-1 Vaccine: Boost-site Controls Secondary B-cell Fates
This work shows that persistent germinal centers (GCs) support continued affinity maturation of founder clones and ipsilateral boosting preferentially engages these lineages in secondary GCs, and identifies disfavored mutational trajectories within the V3-glycan bnAb lineage, revealing intrinsic constraints on bnAb lin...