Frederick L. Locke

Unc-51 like kinase 3 (ULK3) contributes to autophagy and cell survival in multiple myeloma

Despite effective therapies such as proteasome inhibitors, multiple myeloma (MM) patients relapse with refractory disease. Analysis of RNA sequencing data from CD138 + MM patient cells (n = 813) across disease stages identifies an autophagy gene signature. Particularly elevated ULK3 expression is strongly associated wi...