Franziska Kley

Membrane Complexity and Phase Behavior Dictate the Stability of Membrane‐Inserted Aβ 42 Hexamers

Protein–membrane interactions are vital to Alzheimer’s pathogenesis, as lipid environments modulate both the aggregation and toxicity of amyloid‐β (Aβ) peptides. Using atomistic molecular dynamics simulations, this study investigates the stability of an NMR‐derived hexameric Aβ42 β‐barrel in aqueous solution, a fluid 1...