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Author

Franck Coste

2 papers indexed here

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Open access Sep 2026

A new class of inherently efficient SUMOylation substrates

SUMOylation is an essential eukaryotic ubiquitin-like post-translational modification that plays a central role in the regulation of various nuclear processes and stress responses. It canonically occurs at lysine residues within ΨKXE consensus motifs that lie in intrinsically disordered regions or loops and interact sp...

El Hadji Cisse, L. Visticot, Rafael Cepa et al. · 0 citations
Open access Sep 2026

Restoring lysosomal proteostasis reverses steatohepatitis and fibrosis in experimental MASH.

The data indicate that this pharmacological restoration of lysosomal proteostasis engages key transcriptional regulators (Mediator complex) leading to the selective remodeling of pro-fibrotic and inflammatory pathways, leading to the selective remodeling of pro-fibrotic and inflammatory pathways.

Dylan Mastrippolito, Lauriane Gur, Malia Lasalo et al. · 0 citations

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