Author

Francisco N. Barrera

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Review Jul 2026

Conditional Transmembrane Peptides as Allosteric Modulators: Thermodynamic and Functional Perspectives in Membrane Protein Regulation.

Progress in the understanding of the factors underpinning the thermodynamic stability of TM helices in cellular membranes is reviewed, including their discovery in the form of the pHLIP peptide, the factors that determine their membrane insertion, and the basis for their use in cancer theranostics.

Jennifer A. Rybak, Francisco N. Barrera · Chemical Reviews · 0 citations