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Francisco Bezanilla

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Open access Aug 2026

Dynamical Nonequilibrium Molecular Dynamics Simulations Reveal Atomistic Steps of C‑Type Inactivation in Cardiac hERG Channels

hERG is a voltage-gated potassium channel whose malfunction is associated with cardiac pathologies. Unlike other potassium channels, hERG exhibits a peculiarly fast C-type inactivation at the level of the selectivity filter (SF), which has complicated our understanding of its structural dynamics. Molecular Dynamics (MD...

Flavio Costa, C. Bassetto, Francisco Bezanilla et al. · 0 citations
Open access Sep 2026

Mechanistical and structural basis of Kv channel inhibition by 4-aminopyridine

Inhibition of Kv channels by 4-aminopyridine (4AP) improves motor function in multiple sclerosis by enhancing neuronal excitability. The mechanism of inhibition and the structural basis of 4AP binding to Kv channels remain unclear. Here, we determined the structure of the Shaker V369I-I372L-S376T (ILT) mutant bound to...

Bernardo I. Pinto-Anwandter, Richa Agrawal, Trayder Thomas et al. · 0 citations

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