Franceska Ozola

Allosteric switching of Ca2+ permeability in the lysosomal ion channel TPC2 underpins biased agonist activation

Ion channels possess selectivity filters that are hardwired to ensure the selective passage of ions. Lysosomal two-pore channels are unusual as they are able to switch their cation selectivity in an agonist-specific manner, allowing differential control of organellar activity. TPC2 is permeable to Ca2+ when activated b...