Nanoparticle-Mediated and Nanoengineered Drug Delivery for Glaucoma: Preclinical Evidence, Early Human Feasibility, and Translational Challenges
The management of glaucoma with drugs is mostly via the topical route, although these treatments have poor ocular bioavailability. Other problems limiting their therapeutic effect include pre-corneal clearance, corneal and ocular surface barriers, and the need for a long-term treatment regimen. Nanoparticle-mediated dr...