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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Francesco Fiorentino

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Review Open access Oct 2026

What are the potentials of the different sirtuin proteins as therapeutic targets?

INTRODUCTION Sirtuins (SIRT1-7) are NAD+-dependent lysine deacylase and mono-ADP ribosyl transferase enzymes that integrate metabolic status with epigenetic regulation, genome maintenance, mitochondrial homeostasis, and adaptive stress responses. Their dysregulation is implicated in cancer, neurodegeneration, cardiomet...

Emanuele Fabbrizi, G. Hailu, Andrea Mancini et al. · 0 citations
Review Open access Aug 2026

Deubiquitinase-targeting chimeras (DUBTACs): a game-changing approach for targeted protein stabilization in drug discovery.

Targeted protein degradation (TPD) has transformed drug discovery by enabling event-driven elimination of pathogenic proteins, but many diseases arise from protein insufficiency and require restoration rather than removal. Deubiquitinase (DUB)-targeting chimeras (DUBTACs) offer a complementary proximity-pharmacology ap...

G. Hailu, Emanuele Fabbrizi, Andrea Mancini et al. · 0 citations
Review Open access Jul 2026

METTL1/WDR4 Complex: A Novel Epitranscriptomic Target at the Crossroads of RNA Methylation and Drug Discovery

Advances provide the first chemical foothold for therapeutic modulation of m7G pathways and underscore METTL1 as a promising yet complex target requiring careful biological stratification.

Emanuele Fabbrizi, Gebremedhin S. Hailu, Andrea Mancini et al. · 0 citations

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