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Francesca Grisoni

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#federated learning Open access Sep 2026

25 Years of Cardiac Ion Channel QSAR: From hERG Dominance to Multi-Channel Modeling

Abstract In 2013 the Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative proposed multi-channel assessment for proarrhythmic risk evaluation, yet ligand-based predictive modeling has remained largely single-channel. To quantify and explain this mismatch, we survey 155 ligand-based modeling studies on cardiac i...

Mateusz Iwan, Francesca Grisoni, Anastasia Pentina et al. · 0 citations

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