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Author

Fo-Quan Luo

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Open access Sep 2026

Cefuroxime combined with metronidazole alleviates sepsis-induced cognitive dysfunction.

Sepsis-associated encephalopathy (SAE) is a severe complication of sepsis characterized by cognitive dysfunction and synaptic alterations. It is well known that neuroinflammation is involved in the pathogenesis of SAE, and antibiotics remain the mainstay for the treatment of sepsis. However, whether antibiotics could i...

Yue Luo, Mi-Mi An, Jia-Wei He et al. · 0 citations
Aug 2026

Thonningianin a mitigates intervertebral disc degeneration by inhibiting ferroptosis via chelating Fe2+ and regulating the adenosine monophosphate-activated protein kinase (AMPK)/ nuclear factor erythroid 2-related factor 2 (Nrf2)/ glutathione peroxidase 4 (GPX4) pathway.

BACKGROUND Oxidative stress and ferroptosis play critical roles in the pathogenesis of intervertebral disc degeneration (IVDD). Thonningianin A (TA) is a complex polyphenolic ellagitannin found in plants like Thonningia sanguinea, and it exhibits free radical scavenging, anti-superoxide anion generation and metal-chela...

Ye-Kai Zhang, Jiawei Qiu, Han-Wen Zhang et al. · 0 citations

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