Open access
Jan 2026
The HDAC Inhibitor Butyrate Reduces SOD1 Aggregation and Improves Motor Function in C. elegans and Cellular Models of ALS
It is demonstrated that sodium butyrate (NaB), a histone deacetylase inhibitor and microbial metabolite, ameliorates ALS‐related phenotypes in C. elegans and mammalian cell models expressing mutant isoforms of Sod1 linked to ALS.
Fiona Dresel, Martin Michaelis, C. Gourlay
· International Journal of Cel... · 0 citations