Author

FinnGen

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Open access Sep 2026

Clinical history shapes the predictive value of polygenic risk

For most diseases, whether PRS improves prediction beyond clinical data remains unknown, as existing evidence is concentrated in a handful of conditions with established risk models. Using 900,000 participants from UK Biobank and FinnGen, we developed and validated models for predicting 150 diseases and all-cause morta...

D. Usoltsev, I. Molotkov, N. Kolosov et al. · medRxiv · 0 citations

Open access Aug 2026

Multi-biobank genome-wide association study of dermatochalasis implicates genes involved in skin biology and morphology

Objective: The objective of this study was to detect genetic factors associated with dermatochalasis using a genome-wide association study (GWAS) across three large cohorts. Design: GWAS meta-analysis Participants: A total of 13,200 dermatochalasis cases and 962,513 controls were included. Methods: A GWAS meta-analysis...

K. Rajueni, F. Koskimaki, V. Salo et al. · medRxiv · 0 citations