Asymmetric Activation of Tropos Biphenolic Moieties by Isohexides: An Integrated Computational-Experimental Approach.
The asymmetric activation of conformationally dynamic (tropos) biaryls through covalent bond formation with stereochemically stable chiral subunits is a powerful strategy to induce a prevalent diastereomeric conformation on chiral ligands for asymmetric catalysis. This work presents an integrated computational-experime...