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Author

F. Ferreira

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2 papers indexed here

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Open access Oct 2026

Kupffer cells are key mediators of antigen-specific immune tolerance by peptide-coupled red blood cells

Induction of antigen-specific immune tolerance is the most precise method for reverting an autoreactive immune response in diseases such as multiple sclerosis (MS). Coupling red blood cells (RBCs) with a cocktail of MS immunodominant peptides is a promising approach to induce antigen-specific immune tolerance in patien...

Vasileia Kalaitzaki, Pietro Oldrati, Filipa M. Ferreira et al. · 0 citations
Clinical trial Open access Aug 2026

Treatment of multiple sclerosis with peptide-coupled red blood cells induces antigen-specific T regulatory cells.

Inducing antigen-specific immune tolerance is a long-standing aim in organ-specific autoimmune diseases including multiple sclerosis (MS). We developed a therapy based on autologous red blood cells (RBCs) as tolerizing carriers of autoantigens and tested these in an open-label, dose-escalation, phase Ib clinical trial...

Andreas Lutterotti, Thomas Ludersdorfer, M. Docampo et al. · 1 citation

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