Fluoride is widely used for caries prevention due to its effects on mineralized tissues, yet its potential role as a modifier of systemic metal homeostasis remains insufficiently explored. This systematic review synthesizes preclinical evidence on the association between fluoride exposure and changes in metal and semi‐...
N. Macedo-Ribeiro, J. Tostes-Figueiredo, D. da Silva Barbirato et al.· Basic & Clinical Pharmacolog...· 0 citations
AI should complement, not replace, experimental and expert evaluation, supporting a transition toward more predictive, mechanism-informed assessment of real-world chemical exposures, and proposes a framework for regulatory-grade implementation.
J. Domingo, Marília Cristina Oliveira Souza, Fernando Barbosa· Toxicology· 0 citations
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