Fereshte Nejaddehbashi

Combined crocin and treadmill exercise regulate cardiac MicroRNA-23b, nuclear factor Erythroid 2–related factor 2, and tumor necrosis factor-alpha in experimental type 2 diabetes mellitus

Harmaline improves diabetes-associated renal alterations in nicotinamide/streptozotocin-induced diabetic mice: Possible involvement of oxidative stress, inflammation, and renin–angiotensin system signaling

Objective(s): Diabetic nephropathy (DN) is marked by structural and functional kidney damage, driven by oxidative stress, inflammation, and renin–angiotensin system (RAS) dysregulation. Harmaline (HAR), a β-carboline alkaloid with potent antioxidant and anti-inflammatory properties, is a promising multi-target therapeu...

Hesperidin attenuates cisplatin-induced cardiotoxicity in rats through regulating autophagy

Objective: Cisplatin is a well-known anticancer drug whose use has been limited due to a variety of side effects. Evidence has confirmed that cisplatin consumption is associated with cardiac toxicity. Unfortunately, no drug has yet been found to treat cardiac toxicity or reduce the side effects caused by cisplatin. How...

In Vitro Evidences for Renal-Protective Properties of Phloretin in Nephrotoxicity Induced by Bisphenol-A via Mediation of VCAM-1/ICAM-1 Genes Expression

Phloretin significantly attenuates BPA-induced oxidative stress and inflammation in renal tubular cells, suggesting its potential as a natural nephroprotective agent.

Potential Involvement of Redox and Inflammatory Signalling in the Antihyperglycemic and Antioxidant Effects of Harmaline in Male Mice With Type 2 Diabetes

Type 2 diabetes mellitus (T2DM) is strongly associated with oxidative stress and inflammation. Harmaline (HAR), an alkaloid with antioxidant and anti‐inflammatory properties, has been suggested to possess antidiabetic potential. This study investigated the effects of HAR in experimental T2DM and its association with ch...