Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity
Chikungunya virus (CHIKV) replication relies on the multifunctional nsP2 protein, making it an attractive target for antiviral drug discovery. Here, we report the resolution of oxaspiropiperidine 1, a first-in-class inhibitor of the CHIKV nsP2 RNA helicase (nsP2hel), into its constitutive enantiomers and characterizati...
Mark T. Heise, Shubin Liu, Levon Halabelian et al.
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