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Open access Sep 2026

POU2AF2/OCA-T1 coactivates POU2F2 and defines a lineage-specific dependency in diffuse large B-cell lymphoma

Lineage-restricted transcriptional programs establish cell identity and can create selective dependencies in cancer. Here, we identify POU2AF2, encoding the transcriptional co-activator OCA-T1, as a critical lineage-specific dependency in a subset of diffuse large B-cell lymphoma (DLBCL). Pan-cancer dependency analyses...

Rima Tulaiha, Liam Shanley, Amanda Luvisotto et al. · 0 citations
Open access Sep 2026

Spatial chromatin architecture and accessibility co-profiling of mammalian tissues.

Cellular function depends on the spatial organization of cells and biomolecules within the tissue microenvironment. Advances in spatial omics have enabled profiling of molecular features such as transcriptome, proteome and epigenome, and there has been rapid progress of imaging-based approaches to study spatial three-d...

Ping Wang, Juan Wang, Qi-Xuan Wang et al. · 0 citations

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