Feng F. Hong

Adaptive laboratory evolution of Komagataeibacter nataicola for formate-tolerant bacterial cellulose biosynthesis and altered membrane properties.

Formate is a representative weak-acid inhibitor in lignocellulosic hydrolysates and impairs bacterial cellulose (BC) fermentation. Here, adaptive laboratory evolution (ALE) was used to improve formate tolerance in Komagataeibacter nataicola DHU-1 under a defined formate-stress model. Parental DHU-1 was strongly inhibit...

Metabolic targeting by a small extracellular vesicle-based cellulose-GelMA hydrogel restores neurovascular regeneration in diabetic nerve injury

Diabetic peripheral nerve injury (PNI-DM) causes severe sensory and motor dysfunction, yet the metabolic mechanisms impairing neurovascular repair remain unclear. Using histological and molecular analysis of human nerve and muscle tissues, we observed pronounced methylglyoxal-derived hydroimidazolone-1 (MG-H1)/methylgl...

Bacterial cellulose-based nanocomposite doped with activated carbon and silver nanoparticles as filter membrane for antimicrobial activity and water purification