The mechanisms governing PD-L1 expression in breast cancer are highly complex and context-dependent. This article proposes a novel "dual-track" regulatory model to resolve the conflicting roles of estrogen in tumor immunity. Genomic signaling through ER-α suppresses PD-L1 transcription, explaining lower PD-L1 levels in...
Dana R. Crawford, Yung-Ning Yang, Feng-Cheng Liu et al.· Biomedicine & pharmacotherap...· 0 citations
Alphaviruses transmitted by mosquitoes represent an expanding global health concern, yet no specific antiviral agents are currently available for clinical use. Trehalose‐derived glycolipids have emerged as promising host‐modulating compounds with antiviral potential, but their relevance to alphavirus infection has rema...
Jeng-Wei Lu, M. Helal, Guan-Chiun Lee et al.· Journal of Medical Virology· 0 citations
The identification of a novel TLR gene in Chlamys farreri and analysis of its immune functions expand the knowledge of the role of TLR in mollusk immunity and may provide evidence for selecting disease-resistant scallops for cultivation.
Jilv Ma, Feng-Cheng Liu, Zi-Hao Zhang et al.· Developmental and Comparativ...· 0 citations
SiTRAF3 is identified as a pivotal scaffold protein in the echinoid innate immune system, as it significantly drove the promoter activities of nuclear factor kappa-B, activator protein-1, signal transducer and activator of transcription 3, along with multiple inflammatory cytokines and interferon-related elements.
Xiaolong Chu, Feng-Cheng Liu, Yingying Liu et al.· Fish and Shellfish Immunolog...· 0 citations
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