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Author

Félix Veillette

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Open access Sep 2026

Split Cas12a Protospacer Engineering Enables Ultraspecific Recognition of a PAM-Less DNA Strand via an External PAM-Proximal Duplex

CRISPR-Cas12a is a programmable RNA-guided endonuclease whose activation by double-stranded DNA normally depends on the recognition of an adjacent protospacer-adjacent motif (PAM), which constrains target selection in diagnostic applications. Here, we divide the DNA activator into PAM-proximal (Pp) and PAM-distal (Pd)...

G. Lamothe, Félix Veillette, I. Iwe et al. · 0 citations
Open access Sep 2026

Sublayer‐ and pathway‐specific control of CA1 input processing by VIP interneurons

Vasoactive intestinal peptide‐expressing interneurons (VIP‐INs) are prominent regulators of inhibition in hippocampal circuits, yet how their dual inhibitory and disinhibitory actions shape pathway‐specific processing across pyramidal cell sublayers remains unclear. Here, we combined pathway‐specific electrophysiology...

Parisa Iloun, Jordan Grenier, Félix Veillette et al. · 0 citations

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