Felipe S. Barreto

Age-specific genomic and transcriptomic variation reveals limited evidence for cis-regulatory interactions modulating aging in Saccharomyces cerevisiae.

Analysis of genomic and transcriptomic factors contributing to increased replicative age in recombinant yeast populations harboring standing genetic variation suggests that late-life survival is not predominantly governed by background-independent local cis-regulatory interactions, consistent with a polygenic architect...