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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Feilong Zhou

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Oct 2026

Discovery of Novel STING Inhibitors for the Treatment of Severe Acute Pancreatitis

Stimulator of interferon genes (STING) is a promising therapeutic target for severe acute pancreatitis (SAP), but effective small-molecule inhibitors remain limited. Here, structure−activity relationship studies identified compound D4 as a potent STING inhibitor with favorable cellular activity and safety. D4 directl...

Fa-Min Zhang, Xin-Wang Li, Bin Zhu et al. · 0 citations
Jul 2026

Discovery of novel hydroxycamptothecin derivatives as potent Topo I inhibitors for antitumor guided by molecular dynamics.

Camptothecin (CPT) and its derivatives are clinically validated topoisomerase I (Topo I) inhibitors with broad-spectrum antitumor activity and modification at the 10-position of the CPT scaffold represents a promising strategy to enhance binding affinity.

Yixuan Zhang, Hong Wang, Feilong Zhou et al. · 0 citations

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