Glycosylated Hypoxic Tumor-Derived Extracellular Vesicles as a Targeted siRNA Delivery System to Remodel the Immunosuppressive Microenvironment in Pancreatic Cancer.
GalNAc-modified extracellular vesicles (EVs) derived from hypoxic pancreatic cancer cells and loaded with ANXA2 siRNA were developed to modulate the immunosuppressive tumor microenvironment (TME). Characterization confirmed successful surface modification and efficient siRNA loading in EVs with a diameter of approximat...