Early-life maternal separation induces anxiety-like behavior in male mice associated with reduced dentate gyrus neurogenesis and hippocampal inflammatory remodeling.
Early-life adversity increases vulnerability to affective disorders, but the neural alterations underlying sex-dependent susceptibility remain unclear. Here, C57BL/6J mouse pups underwent maternal separation (MS) for 3 h daily from postnatal day 1 to 10, and adult male and female offspring were assessed behaviorally. M...