Fei Hou

Discovery and validation of GNA12circle as a first-trimester plasma eccDNA marker for early-onset preeclampsia

Background Early-onset preeclampsia (EOPE) is a major cause of maternal and perinatal morbidity and is characterized by placental dysfunction, systemic endothelial injury, and hypertensive vascular stress. Because hypertensive disorders of pregnancy may also signal later maternal cardiovascular and cerebrovascular vuln...