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Sep 2026

A Ubiquinone-Reactive Pt(IV) Prodrug Perturbs Mitochondrial Metabolism for Selective Tumor Suppression.

Pt(IV) prodrugs offer a versatile platform for the design of platinum-based antitumor drugs; yet utilizing axial ligands to actively modulate tumor bioenergetics has been less investigated. Herein, we report a mitochondria-directed Pt(IV) prodrug, LA-Pt(IV), in which lipoic acid (LA) serves as a metabolite-reactive axi...

Yi Dai, Wen-Xin Yu, Yi-Chen Yin et al. · 0 citations
Sep 2026

Multiscale alterations of intrinsic neural timescales in anterior ischemic optic neuropathy.

BACKGROUND Anterior ischemic optic neuropathy (AION) is primarily an optic nerve disorder, but loss of visual afferent input may also be associated with cortical reorganization. Intrinsic neural timescale (INT), derived from resting-state fMRI, indexes the temporal persistence of BOLD activity. We examined whether AION...

Xiao-Nan Zhang, Xi-Long Zhang, Yuan-Zhi He et al. · 0 citations

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