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Author

Federico Ballabio

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Open access Oct 2026

Calcium-Driven Activation of Gelsolin: Mechanism and the Active-State Ensemble

Gelsolin is a master regulator of the actin cytoskeleton whose activity is controlled by large Ca2+-dependent conformational transitions of its 6 domains (G1-G6). Despite decades of biochemical and cellular studies, the structural basis of activation of the full-length protein remains poorly understood because active g...

Bruno Stegani, Loic Girois, Federico Ballabio et al. · 0 citations
Open access Oct 2026

Structural dynamics and pH‐regulated membrane binding of the TRAF2‐NC trimer

Abstract Tumor necrosis factor receptor‐associated factor 2 (TRAF2) is a key adaptor in TNF receptor‐signaling that operates as a trimeric assembly. Here we investigate the structural and functional properties of a TRAF2 construct spanning the trimerization and receptor‐binding domains (TRAF2‐NC, residues 266–501). Acc...

F. Cossu, Serena Virili, Bianca Braggiotti et al. · 0 citations
Open access Jul 2026

CP32, a novel anti-oomycete cyclic peptide, interferes with cell-wall deposition in Phytophthora infestans.

CP32 is identified as a promising, targeted anti-oomycete agent with a unique mode of action, targeting the P. infestans cell wall, representing a valuable contribution to the development of sustainable strategies for the control of late blight.

Demetrio Marcianò, S. Rosa, Elena Marone Fassolo et al. · 0 citations

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