Fathima Farsana Orikkalil Kaleel

Design, synthesis, anticancer activity, and molecular docking study of some thiophene-based pyrazoline derivatives

A series of thiophene-based pyrazoline derivatives, designated as 5a-5e was synthesized as potential anti-cancer agents. The first step of the synthetic route involves the preparation of chalcone intermediates through Claisen Schmidt reaction of 2-acetylthiophene with substituted aldehydes. The target compounds 5a-5e w...