Author

Fatemeh Seyednasrollah

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Open access Aug 2026

Oriented binding of transcription factors to nucleosomes remodels chromatin at human promoters.

Transcription factors (TFs) can access nucleosomes via five distinct modes: gyre-spanning, periodic-binding, dyad-binding, and end-binding modes as well as an oriented binding mode, where the TF binding motif shows orientational preference relative to the nucleosome. Here, we report the first structure of an oriented T...

Tianyi Xiao, C. Crowe-McAuliffe, M. Ochmann et al. · Molecules and Cells · 0 citations

Open access Jul 2026

Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5+ tumor stem cell lineage commitment upon Wnt depletion

It is demonstrated that a plastic cell state (PCS) is present already in polyps from patients with familial adenomatous polyposis and in mouse intestinal adenomas, in which PCS is associated with PROX1+ tumor stem cells.

Marika Lassila, Fatemeh Seyednasrollah, Cinzia Bessone et al. · Science Advances · 0 citations