A Streamlined One-Pot Extraction Method Enables High-Sensitivity Top-Down Proteomic Characterization of Phospholamban from Biopsy-Scale Cardiac Tissue
A streamlined Azo-enabled one-pot extraction strategy for high-sensitivity top-down analysis of PLN that reduces the required tissue input to 1 mg while preserving analytical performance and establishing a practical strategy for TDP of PLN proteoforms from biopsy-scale and other sample-limited myocardial specimens.
Isabella R. Clemmer, Holden T. Rogers, M. C. Wilson et al.
· Journal of the American Soci... · 0 citations