Aug 2026
An engineered oncolytic parapoxvirus induces immunogenic tumor cell death and displays antitumor efficacy by enhancing T cell responses.
These findings establish ORFVΔ-IL15 as a novel therapeutic agent that integrates oncolytic and immunoregulatory functions, demonstrating robust tumor-suppressive efficacy and offering a promising strategy for next-generation oncolytic virus engineering.
Qi Li, Jing Lin, Fei Gao et al.
· Biochemical Pharmacology · 0 citations