Review
Open access
Sep 2026
SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential
The structural and catalytic features of SIRT1 are summarized, the mechanisms linking SIRT1 to cognitive impairment across major neurodegenerative diseases are examined, and the opportunities and limitations of SIRT1‐targeted therapeutic strategies are evaluated.
Jia-Bin Duan, Jia-Qiang Liu, Qing-Sheng Meng et al.
· The FASEB Journal · 0 citations