Open access
Oct 2026
Myeloid Suppressor Cells Drive HCC Invasiveness via the THBS1-SDC4 Pathway.
BACKGROUND & AIMS Monocytic myeloid-derived suppressor cells (M-MDSCs) accumulate in hepatocellular carcinoma (HCC), but their activation and tumor-promoting mechanisms remain unclear. We investigated how stromal-myeloid-tumor crosstalk promotes HCC invasiveness and epithelial-mesenchymal transition (EMT). METHODS We...
Si-Yuan Liu, Jing-Hua Gu, Shu-Yan Sheng et al.
· JHEP Reports · 0 citations