Author

Fang-Tsyr Lin

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Open access Aug 2026

Development of a structurally distinct TopBP1 inhibitor that enhances PARP blockade and reverses osimertinib resistance

CS18 is established as a chemically distinct TopBP1 inhibitor with translational potential to overcome therapeutic resistance and advance precision oncology.

Fang-Tsyr Lin, Shwu-Jiuan Lin, Kang Liu et al. · Science Advances · 0 citations