Fang Dong

[Diabetes-driven hematopoietic remodeling and metabolic memory].

[Applications and advances of single-cell omics technologies in hematopoietic stem cell research].

Monocyte Galectin-9 is associated with CD8⁺ T-cell dysfunction and early relapse after haploidentical hematopoietic stem cell transplantation

Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) stands as a leading curative approach for AML in China. However, relapse remains a major challenge for patient survival, often occurring within six months post-transplant and ass...

P-selectin delineates conserved functional heterogeneity in early hematopoietic stem cell aging in humans and mice

This study identifies P-selectin (Selp) as an evolutionarily conserved surface marker that captures functional and transcriptomic heterogeneity within the elderly hematopoietic stem cell (HSC) compartment.

KLF4/MLL3 complex axis drives NRBP2 transcription to eliminate acute myeloid leukemia cells.

A molecular mechanism by which KLF4 governs AML progression is revealed, providing a novel therapeutic target and a potential small-molecule inhibitor for AML treatment.

Engineered lipid nanoparticles for in vivo and durable editing of haematopoietic stem cells within humanized mice.

An LNP is reported that efficiently delivers reporter mRNA to human HSPCs both in ex vivo and in vivo settings when conjugated with the anti-CD34 antibody (CD34/LNPDP).