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Open access Oct 2026

Association of the C-reactive protein-to-HDL cholesterol ratio with all-cause mortality in Chinese adults with impaired renal function: a prospective cohort study

Inflammation and dyslipidemia contribute to excess mortality in chronic kidney disease (CKD). The C-reactive protein-to-high-density lipoprotein cholesterol (CRP/HDL-C) ratio integrates these pathways, but its association with mortality among individuals with impaired renal function remains unclear. This prospective co...

Yuan Wang, Fan Zhang, Liu-Yan Huang et al. · 0 citations
Open access Sep 2026

Higher cystatin C, but not creatinine, predicts frailty risk in individuals with normal kidney function

Objective This study investigates the associations of creatinine and cystatin C with frailty risk in individuals with normal kidney function, using data from the Health and Retirement Study (HRS) and the China Health and Retirement Longitudinal Study (CHARLS). Methods We used CKD-EPI to estimate glomerular filtration r...

Fan Zhang, Yue Xing, Yan Bai et al. · 0 citations
Open access Aug 2026

Joint effects of physical activity and depressive symptoms on chronic kidney disease risk: Findings from the CHARLS cohort.

INTRODUCTION Physical inactivity and depressive symptoms are established risk factors for chronic kidney disease (CKD), but their joint effects on incident CKD remain unclear. This study investigates the independent and joint associations of physical activity and depressive symptoms with incident CKD in middle-aged and...

Fan Zhang, Xue-Ling Li, Yi-Bo Ding et al. · 0 citations
Review Open access Oct 2026

Non-pharmacological interventions and frailty-related outcomes in maintenance dialysis patients: a narrative review of evidence published since 2020

Frailty is common among adults receiving maintenance hemodialysis (HD) or peritoneal dialysis (PD) and is associated with mortality, hospitalization, impaired physical function, and reduced quality of life. In a multimorbid population vulnerable to polypharmacy and treatment burden, non-pharmacological approaches may b...

Fan Zhang, Kai-Li Lu, Wanhaier Abudoureheman et al. · 0 citations
Open access Sep 2026

Differential Associations of Healthy Lifestyle Latent Classes with Glycemic Transitions in Prediabetes: An Observational Study Based on CHARLS

Highlights What are the main findings? Over a four-year follow-up, among older adults with prediabetes in China, the patterns of glycemic transition were as follows: 1644 individuals (65%) remained in the prediabetic range, 322 (13%) progressed to diabetes, and 563 (22%) returned to normal glucose levels. Three distinc...

Min Ma, Xue-Qin Ma, Huo-Ling Pan et al. · 0 citations

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