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Sep 2026

Abstract A050: NEIL2 regulates RNA polymerase II dynamics to suppress transcription–replication conflicts in pancreatic cancer

Transcription–replication conflicts (TRCs), arising from spatiotemporal interference between transcription and replication machinery, are major sources of genome instability in cell. In pancreatic ductal adenocarcinoma (PDAC), oncogenic KRAS promotes TRC formation, and pharmacological exacerbation of endogenous T...

Fan Meng, Tony Fernandez, C. Luan et al. · 0 citations
#protein folding Open access Sep 2026

Second-Generation AOH1996 Analogues with Enhanced Pharmacological Properties for Targeting PCNA

Second-generation AOH analogues with enhanced pharmacological properties were created through scaffold optimization, and both compounds induced robust G2/M arrest at lower concentrations than the parent molecule and significantly enhanced transcription–replication conflicts in pancreatic cancer cells.

Pouya Haratipour, Maryam Zangi, Long Gu et al. · 0 citations

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