Open access
Jul 2026
A highly penetrant LMNA R541C variant associated with dilated cardiomyopathy leads to dysregulation in metabolism and proliferation pathways in stem cell-derived cardiomyocytes
These results implicate perturbed gene expression and pathways that may contribute to the severe phenotypes in LMNA-R541C and suggest several drug classes including multiple cardiac glycosides as potential targeted therapeutic candidates to be explored.
Thomas E. Keller, Ci Koehring, Brett W. Higgins et al.
· bioRxiv · 0 citations