Author

Fabian Meyer

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Open access Jul 2026

A tailored CoA ligase–N-acyltransferase cascade for on-DNA amide bond formation gives access to broad substrate scope

DNA-encoded chemical library (DEL) technology is a powerful tool in early-stage drug discovery. Although widely applied in industry and academia, challenges persist in generating DELs with high quality and chemical diversity. Low yields in building-block incorporation, limited selectivity and, most importantly, DNA dam...

Daniel Schaub, Alice Lessing, Fabian Meyer et al. · Nature Catalysis · 1 citation

Open access Jul 2026

ThermoFusion: A Multimodal Deep Learning Framework for Generalizable Prediction of Enzyme Thermostability

ThermoFusion, a hybrid deep learning framework that integrates 3D protein structure embeddings from ThermoMPNN with sequence-based embeddings from the pretrained protein language model ESM2 to predict the effects of single-point mutations on protein stability is presented.

Yao Wei, I. Eberini, Fabian Meyer · bioRxiv · 0 citations