Author

Fa Zhang

3 papers indexed here

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Open access Sep 2026

CryoFlex characterizes structural motion between conformations directly from cryo-EM density maps

Heterogeneous cryo-EM reconstruction methods can resolve multiple conformational states, but understanding their functional implications often requires determining which regions move between states and quantifying their displacement magnitudes. Comparing atomic models can quantify motion, but flexible regions are often...

Hao Dong, Fu-Wei Li, Yuan-Bo Chen et al. · bioRxiv · 0 citations

Open access Oct 2026

CryoTriplane: triplane-based neural radiance field representation for high-resolution cryo-EM 3D homogeneous reconstruction

Abstract Motivation Determining the three-dimensional (3D) structure of proteins is a cornerstone of structural biology, providing essential insights into their underlying biological mechanisms and functional roles. Cryogenic electron microscopy (cryo-EM) single-particle analysis allows researchers to investigate biomo...

Yi-Ran Cheng, Bin-Tao He, Qiong Zeng et al. · Bioinformatics · 0 citations

Open access Sep 2026

CryoMV: Structure-Prior-Guided Modeling and Real-Particle Validation of Continuous Conformational Transitions in Cryo-EM

Continuous protein conformations are essential for understanding fundamental biological processes and supporting drug discovery. Although cryo-EM can resolve individual states at high resolution, recovering continuous heterogeneity from 2D particle images remains challenging. High noise, motion blur, and limited struct...

Fu-Wei Li, Hao Dong, Shuai Tang et al. · bioRxiv · 0 citations