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Open access Aug 2026

PSMB5-centered immunotherapy resistance signature predicts prognosis and drives CD8+ T cell exclusion in lung adenocarcinoma

Background: Immune checkpoint inhibitors (ICIs) achieve limited response rates in lung adenocarcinoma (LUAD), and the mechanisms underlying immunotherapy resistance remain poorly understood. Robust predictive biomarkers are urgently needed. Methods: We integrated single cell transcriptomic data, multicohort bulk RNAseq...

L. Lin, F. Zheng, Y. Sun et al. · 0 citations

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