Author

F. Woller

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Open access Jul 2026

Beyond the classical plasma secretome: genetic architecture and disease associations of the expanded human plasma proteome in 13,445 Europeans

Circulating plasma proteins are key biomarkers and therapeutic targets, now measurable at scale through high-throughput technologies, yet whether expanding proteomics platforms beyond the classical plasma secretome enhances genetic discovery and causal inference remains poorly understood. Here, we use an expanded SomaS...

S. Cadiou, E. Konig, A. Mapelli et al. · medRxiv · 0 citations

Open access Nov 2025

SignifiKANTE: efficient P-value computation for gene regulatory networks

SignifiKANTE employs gene clustering based on the 1-Wasserstein distance to create a small, constant number of background distributions which enables the simultaneous computation of approximate empirical P-values for multiple target genes, which reduces runtime by orders of magnitudes.

F. Woller, Paul Martini, Souptik Sen et al. · bioRxiv · 1 citation