Cationic membrane-active drugs are an important focus of antibiotic research, yet their potential is often limited by poor selectivity. Here, we establish steric protection of cations by modular triethylene glycol as a chemical design framework to decouple antimicrobial potency from cytotoxicity. Using antipsychotics...
Marc Seewald, Marla Stamen, Jian Li et al.· JACS Au· 0 citations
This cross-sectional study investigates the spectrum and proportion of multidrug-resistant (MDR) bacteria isolated from clinical samples processed at the regional microbiology laboratory of Lambaréné, Gabon. Bacteriological results from 2017 to 2023 were retrospectively analysed to assess the rates of non-susceptibilit...
M. D. Agbanrin, BR Adegbite, C. S. Gouleu et al.· PLOS Global Public Health· 0 citations
Introduction Methicillin-resistant Staphylococcus aureus (MRSA) is a human pathogen of global public health importance. A key element of MRSA decolonization strategies is the administration of mupirocin, an antibiotic also used to treat superficial skin infections. However, the emergence and global increase of mupiroci...
A. Shittu, Olga Perovic, Franziska Layer-Nicolaou et al.· Frontiers in Cellular and In...· 0 citations
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